In several of my SharePoint projects I'm using a WinForm application to test and trigger SP code.
Sometimes I have had big problems when recompiling the SP projects and generating the PDB file. This time I disabled the VSHOST option for my WinForm project and the problem was solved.
VS spawns a new winformexe.vshost.exe process each time I tried to kill it with Process Explorer, so it kept me from recompiling the other SP corrctly.
How to: Disable the Hosting Process